Dimethylformamide → HCID 10255773, compound

HRID 863690Notes

Reaction equation

HRID 863690 reaction equation
[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:38][CH2:37][N:12]2[C:13]3[C:18]([C:19]([C:20]4[C:21](=[O:36])O[C:23](=[O:35])[C:24]=4[C:25]4[C:33]5[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=5)[N:27]([CH3:34])[CH:26]=4)=[C:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:7])([CH3:4])([CH3:3])[CH3:2].C[N:40](C)C=O>N>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:38][CH2:37][N:12]2[C:13]3[C:18]([C:19]([C:20]4[C:21](=[O:36])[NH:40][C:23](=[O:35])[C:24]=4[C:25]4[C:33]5[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=5)[N:27]([CH3:34])[CH:26]=4)=[C:11]2[CH2:10]1)=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 6228DimethylformamideHCID 10436408HCID 10436408, compound

Product 1

HCID 10255773HCID 10255773, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

A solution of 80 mg of 3-[8-t-butoxyformamido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)furan-2,5-dione in 2 ml of dimethylformamide and 2 ml of 33% aqueous ammonia was heated to 100° C. for 1 hour. The solution was cooled and gave 60 mg of 3-[8-t-butoxyformamido-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione of melting point 153°-155° C.

Workup

  1. temperatureThe solution was cooled

Sources & evidence

ORD record
ord-2caa38663dff413c9b42769a39912807
Source dataset
uspto-grants-1998_02
Patent number
US05721245

Reaction notes

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