Hydrochloric Acid → HCID 19050640, compound

HRID 863757Notes

Reaction equation

HRID 863757 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[C:9](=[O:10])[O:8][C:7]2([C:13]1[N:18]=[C:17]([O:19][CH3:20])[CH:16]=[C:15]([O:21][CH3:22])[N:14]=1)[OH:12].[C:23](OC(=O)C)(=[O:25])[CH3:24].Cl>N1C=CC=CC=1>[C:23]([O:12][C:7]1([C:13]2[N:14]=[C:15]([O:21][CH3:22])[CH:16]=[C:17]([O:19][CH3:20])[N:18]=2)[C:6]2[C:11](=[C:2]([Cl:1])[CH:3]=[CH:4][CH:5]=2)[C:9](=[O:10])[O:8]1)(=[O:25])[CH3:24]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 19050642HCID 19050642, compound

Product 1

HCID 19050640HCID 19050640, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

1.1 g of 7-chloro-3-(4,6-dimethoxy-2-pyrimidinyl)-3-hydroxy-phthalide is dissolved in 20 ml of pyridine and 0.3 ml of acetic anhydride added with stirring. After stirring for 20 min the mixture is poured into 2N HCl and extracted with two portions of ethyl acetate. The combined ethyl acetate extracts are washed once with 2N HCl, once with H2O and once with brine and dried over magnesium sulfate. Filtration and evaporation produced the title compound as a white solid, m.p. 213°-215°.

Workup

  1. stirringAfter stirring for 20 min the mixture
  2. extractionextracted with two portions of ethyl acetate
  3. washThe combined ethyl acetate extracts are washed once with 2N HCl, once with H2O and once with brine
  4. dry with materialdried over magnesium sulfate
  5. filtrationFiltration and evaporation

Sources & evidence

ORD record
ord-78c926f7dfae46a29d3baa7acbdc4fb2
Source dataset
uspto-grants-1996_10
Patent number
US05561101

Reaction notes

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