HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Benzaldehyde, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Benzaldehyde, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- | HCID 10900635 | 93% |
Reaction Steps
A solution of 2-hydroxybenzaldehyde (500 mg, 0.44 ml, 4.09 mmol), imidazole (685 mg) and tert-butyldimethylsilyl chloride (680 mg) in DMF is stirred for 24 hours at room temperature. After hydrolysis and customary extraction, chromatography gives 28 (890 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05561119 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-aa289e50a0f44146b6049ebd2c54f19c |
| Source note | uspto-grants-1996_10 |