HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 4-Nitrophenyl 2-(tert-butyldimethylsilyloxy)benzyl carbonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| Reactant | Benzenemethanol, 2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- | HCID 10966587 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-Nitrophenyl 2-(tert-butyldimethylsilyloxy)benzyl carbonate | HCID 19420313 | 91.2% |
Reaction Steps
The alcohol 29 (135 mg, 0.56 mmol) is dissolved in ethyl acetate (0.82 ml). Pyridine (0.081 ml) is then added, followed by 4-nitrophenyl chloroformate (275 mg, 2.4 eq.). After one night at room temperature, the solvent is evaporated off. Chromatography on silica gel gives the carbonate 30 (206 mg, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05561119 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-f23e93dd60364323b0e522f125da619d |
| Source note | uspto-grants-1996_10 |