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HRID863784

反应详情

EQUATION

反应方程式

HRID 863784 的结构方程式

REACTANTS

反应物

3
结构：Cc1cc([N+](=O)[O-])ccc1O
HCID7442

Phenol, 2-methyl-4-nitro-

C7H7NO3

结构：[Cl][Sn]([Cl])([Cl])[Cl]
HCID24287

Tetrachlorostannane

Cl4Sn

结构：CC(=O)OC[C@H]1O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
HCID94752

.beta.-D-Galactopyranose, 1,2,3,4,6-pentaacetate

C16H22O11

PRODUCTS

生成物

1
结构：CC(=O)OC[C@H]1O[C@H](Oc2ccc([N+](=O)[O-])cc2C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O
HCID53830823

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

SnCl4 (0.6 ml) is added slowly to a solution of 2-methyl-4-nitrophenol (ref.: J. S. ANDERSON and K. C. BROWN, Synthetic Commun., 13, 233-236, 1983) and 1,2,3,4,6-penta-O-acetyl-β-D-galactose (1 g, 2.56 mmol), kept at room temperature. The reaction mixture is then stirred under nitrogen for 12 hours at 60° C. After hydrolysis in iced water, extraction with CH2Cl2, followed by washing with a saturated solution of sodium bicarbonate and then water, gives 42, which is then purified by chromatography on silica gel (yield=45%).

WORKUP

后处理

  1. customkept at room temperature
  2. extractionextraction with CH2Cl2
  3. washby washing with a saturated solution of sodium bicarbonate