HRID863785

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2879

p-Cresol

C7H8O

结构：CC(=O)OC[C@H]1OC(OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O

HCID2729838

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OC[C@H]1O[C@H](Oc2ccc(C)cc2)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]1OC(C)=O

HCID54141638

未命名化合物

收率 40%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID3007855

Zinc chloride

Cl2Zn

PROCEDURE

实验过程

According to scheme XIV, the coupling of penta-O-acetyl-D-galactopyranose (36 g, 92 mmoles) with p-cresol (30 g, 280 mmoles) is carried out by fusion in the presence of anhydrous ZnCl2 (1.8 g) at 160° C. for 30 minutes, according Helferich technique. After cooling, a chromatography on a column of 60H silica (solvent:hexane-ethyl acetate: 90/10-v/v) is directly performed on the mixture and gives 15 g, yield=40% of 4-methylphenyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside, which crystallises in ethanol. Its analytical characteristics are identical as the one described before.

WORKUP

后处理

temperatureAfter cooling