反应详情

温度

0 °C

To a solution of 4-bromo-t-butyldimethylsilyloxybenzene (8.3 g; 29 mmol) in THF (60 ml) at -78° C. is added a solution of butyllithium in hexane (14 ml; 35 mmol) over 10 minutes. This is allowed to stir 1 hour and 2-chlorobenzoxazole (4 ml; 35 mmol) is added dropwise over 5 minutes. After stirring 15 minutes, the reaction is allowed to warm to 0° C. and is quenched with MeOH. This is then poured into 1N HCl and after stirring 1 hour is extracted with ethyl acetate. The organic extracts are dried (MgSO4) and then concentrated to yield 4-(benzoxazol-2-yl)phenol which is used directly in Step C.

1. stirringAfter stirring 15 minutes
2. customis quenched with MeOH
3. additionThis is then poured into 1N HCl
4. stirringafter stirring 1 hour
5. extractionis extracted with ethyl acetate
6. dry with materialThe organic extracts are dried (MgSO4)
7. concentrationconcentrated