HRID863868

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID3283

Diethyl Ether

C4H10O

结构：COc1ccc(C(C#N)(CCCN2CCc3cc(OC)c(OC)cc3C2)Sc2ccc(C)cc2)cc1OC

HCID10744844

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccccc2C(C#N)(CCCN2CCc3cc(OC)c(OC)cc3C2)Sc2ccc(C)cc2)cc1OC.Cl

HCID67811830

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

To a solution of 1.43 g of α-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolinepentanenitrile in 40 mL of diethyl ether, with stirring, is added 0.617 mL of a 4.71M solution of hydrogen chloride in absolute ethyl alcohol. The reaction mixture is then stirred for 15 hours while sealed. The title product is then collected by filtration, washed with ether, and dried under vacuum to give 1.32 g of the desired product as pink crystals.

WORKUP

后处理

customwhile sealed
filtrationThe title product is then collected by filtration
washwashed with ether
customdried under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-182cd74aa14a47748907647a839f6c94
来源数据集: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05561141
来源说明: uspto-grants-1996_10

反应 SMILES

CO[C:3]1[CH:4]=[C:5]([C:11]([S:31][C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)([CH2:14][CH2:15][CH2:16][N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1OC.[ClH:39].[CH2:40]([O:42][CH2:43][CH3:44])C>C(O)C>[ClH:39].[CH3:40][O:42][C:43]1[CH:44]=[C:19]([C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][C:5]=2[C:11]([S:31][C:32]2[CH:33]=[CH:34][C:35]([CH3:38])=[CH:36][CH:37]=2)([CH2:14][CH2:15][CH2:16][N:17]2[CH2:26][CH2:25][C:24]3[C:19](=[CH:20][C:21]([O:29][CH3:30])=[C:22]([O:27][CH3:28])[CH:23]=3)[CH2:18]2)[C:12]#[N:13])[CH:20]=[CH:21][C:22]=1[O:27][CH3:28]