Hydrochloric Acid → HCID 19042106, compound

HRID 863881Notes

Reaction equation

HRID 863881 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([S:39][C:40]2[CH:45]=[CH:44][C:43]([CH3:46])=[CH:42][CH:41]=2)([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][C:23]([O:31][CH2:32][CH2:33][N:34]4[CH:38]=[CH:37][N:36]=[CH:35]4)=[C:24]([O:29][CH3:30])[CH:25]=3)[CH2:20]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[ClH:47]>C(OCC)C.C(O)C>[ClH:47].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]([S:39][C:40]2[CH:41]=[CH:42][C:43]([CH3:46])=[CH:44][CH:45]=2)([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][N:19]2[CH2:28][CH2:27][C:26]3[C:21](=[CH:22][C:23]([O:31][CH2:32][CH2:33][N:34]4[CH:38]=[CH:37][N:36]=[CH:35]4)=[C:24]([O:29][CH3:30])[CH:25]=3)[CH2:20]2)[C:12]#[N:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 10326801HCID 10326801, compound

Product 1

HCID 19042106HCID 19042106, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 0.8 g of α-(3,4-dimethoxyphenyl)-3,4-dihydro-7-[2-(1H-imidazol-1-yl)ethoxy]-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile in 100 mL of diethyl ether and 5 mL of ethyl alcohol is added 0.83 mL of 4.5M hydrochloric acid in ethyl alcohol. The solution is stirred for 20 minutes and the white precipitate is collected and washed three times with small portions of diethyl ether. The solid is dried in vacuo affording 0.84 g of the desired product as a white solid. mp 70° C. (dec). Calcd for C37H49.75 N4O6SCl1.75 : C=60.00, H=6.77, N=7.57, Cl=8.38, S=4.32 Found C=60.10, H=6.86, N=7.21, Cl=8.78, S=4.28

Workup

  1. customthe white precipitate is collected
  2. washwashed three times with small portions of diethyl ether
  3. customThe solid is dried in vacuo

Sources & evidence

ORD record
ord-1dd64f0e59e4480885608c75bb908518
Source dataset
uspto-grants-1996_10
Patent number
US05561141

Reaction notes

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