4-Methylbenzenethiol → 1-[[(4-Methylphenyl)thio]methyl]-4-(trifluoromethoxy)benzene

HRID 863905Notes

Reaction equation

HRID 863905 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[F:9][C:10]([F:21])([F:20])[O:11][C:12]1[CH:19]=[CH:18][C:15]([CH2:16]Cl)=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:16][C:15]2[CH:18]=[CH:19][C:12]([O:11][C:10]([F:9])([F:20])[F:21])=[CH:13][CH:14]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 78114-MethylbenzenethiolHCID 27772614-(Trifluoromethoxy)benzyl Chloride

Product 1

HCID 108516111-[[(4-Methylphenyl)thio]methyl]-4-(trifluoromethoxy)benzeneYield 80.1%

Procedure

The procedure of Example 87 is repeated using 11.8 g of p-thiocresol and 9.6 g of 4-(trifluoromethoxy)benzyl chloride. This affords 10.9 g of the desired product as white crystals. mp 74°-76° C. MS(CI): m/z 299(MH+). Calcd for C15H13F3OS: C=60.39, H=4.39, F=19.11, S=10.75 Found C=60.33, H=4.26, F=19.34, S=11.01

Sources & evidence

ORD record
ord-98e1b32b22294ace80b4a3c5e59c50d2
Source dataset
uspto-grants-1996_10
Patent number
US05561141

Reaction notes

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