反应详情

To a solution of 2..5 g (9.45 mmol) of 4-[3-(N-(2-thienylmethyl)amino)propylthio]pyridine and 1.32 ml (9.45 mmol) of triethylamine in 50 ml of methylene chloride, 1.1 ml (9.45 mmol) of benzoyl chloride was added under ice-cooling with stirring. The mixture was stirred at room temperature for 30 minutes. The reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water and dried, and the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to obtain 1.25 g of the desired compound (yield: 35.9%, yellow oil).

1. temperaturecooling
2. stirringThe mixture was stirred at room temperature for 30 minutes
3. washThe reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate and water
4. customdried
5. distillationthe solvent was distilled off
6. customThe residue was purified by column chromatography (eluent: ethyl acetate)