反应详情

A solution of 1.5 g (7.4 mmol) of 2-hydroxymethylene-3,3,6-trimethyl-1-indanone, 0.55 g (6.1 mmol) of (RS)-1-hydrazino-2-propanol and 100 mg of p-toluenesulfonic acid in 100 ml of anhydrous toluene was heated on a water separator for 2 hours. After concentration in a vacuum, the reaction mixture was purified by column chromatography on silica gel (ethyl acetate/hexane 4:1). 1.6 g (84%) of (RS)-1-(4,4,7-trimethyl-1,4-dihydro-indeno[2,1-c]-pyrazol-1-yl)-propan-2-ol were obtained as a yellow oil which was used directly in the next reaction.

1. concentrationAfter concentration in a vacuum
2. customthe reaction mixture was purified by column chromatography on silica gel (ethyl acetate/hexane 4:1)