反应详情

A solution of 1.4 g (8.04 mmol) of 2-hydroxymethylene-6-methyl-1-indanone, 0.87 g (9.65 mmol) of (RS)-1-hydrazino-2-propanol and 100 mg of p-toluenesulfonic acid in 100 ml of anhydrous toluene was heated on a water separator for 2 hours. After concentration in a vacuum, the reaction mixture was purified by column chromatography on silica gel (ethyl acetate/hexane 4:1). 1.7 g (93%) of (RS)-1-(7-methyl-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol were obtained as a yellow oil which was used directly in the next reaction.

1. concentrationAfter concentration in a vacuum
2. customthe reaction mixture was purified by column chromatography on silica gel (ethyl acetate/hexane 4:1)