反应详情

A solution of 1.63 g (7.98 mmol) of 2-hydroxy-methylene-7-methoxy-1-tetralone, 0.87 g (9.65 mmol) of (RS)-1-hydrazino-2-propanol and 100 mg of p-toluenesulfonic acid in 100 ml of anhydrous toluene was heated on a water separator for 1.5 hours. After concentration in a vacuum, the reaction mixture S was purified by column chromatography on silica gel (ethyl acetate/hexane 1:1). 1.52 g (74%) of (RS)-1-(4,5-dihydro-8-methoxy-1H-benz[g]indazol-1-yl)-propan-2-ol were obtained as a yellow oil which was used directly in the next reaction.

1. concentrationAfter concentration in a vacuum
2. customthe reaction mixture S was purified by column chromatography on silica gel (ethyl acetate/hexane 1:1)