反应详情

A solution of 0.5 g (2.45 mmol) of 2-hydroxymethylene-6-ethoxy-1-indanone, 0.27 g (2.94 mmol) of (R)-1-hydrazino-2-propanol and 50 mg of p-toluenesulfonic acid in 50 ml of anhydrous toluene was heated on a water separator for 1 hour. After concentration in a vacuum, the reaction mixture was purified by column chromatography on silica gel (ethyl acetate). 0.49 g (77%) of (R)-1-(7-ethoxy-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl )-propan-2-ol was obtained as a yellow solid which was used directly in the next as reaction.

1. concentrationAfter concentration in a vacuum
2. customthe reaction mixture was purified by column chromatography on silica gel (ethyl acetate)