4-n-Octyloxyphenylboronic Acid (contains varying amounts of Anhydride) → 2-Fluoro-3,6-bis (4-octyloxyphenyl)pyrazine

HRID 864267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 864267
Br[C:2]1[C:7]([F:8])=[N:6][C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:11][CH:10]=2)=[CH:4][N:3]=1.[CH2:24]([O:32][C:33]1[CH:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1)[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31]>>[F:8][C:7]1[C:2]([C:36]2[CH:37]=[CH:38][C:33]([O:32][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:34][CH:35]=2)=[N:3][CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[CH:11][CH:10]=2)[N:6]=1

Komponenten

3

Edukt 2

HCID 39772844-n-Octyloxyphenylboronic Acid (contains varying amounts of Anhydride)HCID 218046332-Bromo-3-fluoro-5-(4-octyloxyphenyl)pyrazine

Produkt 1

HCID 121306862-Fluoro-3,6-bis (4-octyloxyphenyl)pyrazineAusbeute 73,7 %

Versuchsvorschrift

An analogous reaction to Example 1b of 2.00 g (5.25 mmol) of 2-bromo-3-fluoro-5-(4-octyloxyphenyl)pyrazine (prepared as described in Example 1a-1c) and 1.31 g (5.25 mmol) of 4-octyloxyphenylboronic acid gives 1.96 g of 2-fluoro-3,6-bis (4-octyloxyphenyl)pyrazine. ##STR18## The compound has the following phase sequence:

Quellen und Nachweise

ORD-Eintrag
ord-51e4d89e4c494358a4ba6cae0a56e442
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05562859

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