反应详情

In an analogous reaction to Example 5a, 3.04 g (11.60 mmol) of triphenylphosphine, 1.82 ml (11.60 mmol) of diethyl azodicarboxylate, 2.00 g (7.00 mmol) of 2-fluoro-3-octyl-6-(4-hydroxyphenyl)pyrazine and 1.67 g (11.60 mmol) of (2S,3S)-3-pentyloxiran-2-ylmethanol give 1.20 g of [(2S,3S)-3-pentyloxiran-2-yl]methyl 4-(2-fluoro-3-octylpyrazin-6-yl)phenyl ether of [α]D20 (c = 0,995 in CHCl3)=-16.58. ##STR28##