Diphosgene → HCID 19418707, compound

HRID 864322Notes

Reaction equation

HRID 864322 reaction equation
[N:1]([C:4]1[CH:5]=[C:6]([S:10][CH2:11][C:12]([O:14][C:15]([CH3:18])(C)C)=[O:13])[CH:7]=[CH:8][CH:9]=1)=[C:2]=[O:3].N[C:20]1C=C(SC(C)C(OCC)=O)C=CC=1.ClC(OC(Cl)(Cl)Cl)=O>>[N:1]([C:4]1[CH:5]=[C:6]([S:10][CH:11]([CH3:20])[C:12]([O:14][CH2:15][CH3:18])=[O:13])[CH:7]=[CH:8][CH:9]=1)=[C:2]=[O:3]

Participants

4

Reactant 3

HCID 10426DiphosgeneHCID 19418724HCID 19418724, compoundHCID 54017826HCID 54017826, compound

Product 1

HCID 19418707HCID 19418707, compound

Procedure

Ethyl 2-(3-isocyanatophenylthio)propionate can be obtained in a manner analogous to that described in Example 1 for the preparation of tert-butyl (3-isocyanatophenylthio)acetate, but starting for 1 g of ethyl 2-(3-aminophenylthio)propionate, 0.54 cm3 of trichloromethyl chloroformate and 0.09 g of carbon. 1.18 g of ethyl 2-(3-isocyanatophenylthio)propionate are thus obtained in the form of an oil which is used as such in the subsequent syntheses.

Sources & evidence

ORD record
ord-16f759cf27834b85827c507ad8916b36
Source dataset
uspto-grants-1996_10
Patent number
US05563136

Reaction notes

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