Ammonia → HCID 19418698, compound

HRID 864323Notes

Reaction equation

HRID 864323 reaction equation
N.C([O:5][N:6]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([N+:17]([O-:19])=[O:18])[CH:12]=1)[C:7](=[O:9])[CH3:8])(=O)C>CO>[N+:17]([C:13]1[CH:12]=[C:11]([CH2:10][N:6]([C:7](=[O:9])[CH3:8])[OH:5])[CH:16]=[CH:15][CH:14]=1)([O-:19])=[O:18]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 19418710HCID 19418710, compound

Product 1

HCID 19418698HCID 19418698, compoundYield 83.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

N-{(3-Nitrophenyl)methyl}acetohydroxamic acid can be obtained in the following manner: 22 cm3 of an 17N aqueous solution of ammonia are added at a temperature near to 25° C. to a solution of 3.55 g of N-acetoxy-N-{(3-nitrophenyl)methyl}acetamide in 120 cm3 of methanol. The reaction mixture is stirred for two hours at a temperature near to 25° C., and then concentrated under reduced pressure. The residue is dissolved in 100 cm3 of a saturated aqueous solution of sodium chloride, dried over magnesium sulphate and concentrated under reduced pressure. 2.46 g of N-{(3-nitrophenyl)methyl}acetohydroxamic acid melting at 80° C. are thus obtained.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe residue is dissolved in 100 cm3 of a saturated aqueous solution of sodium chloride
  3. dry with materialdried over magnesium sulphate
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9329bcad658a44228dfbd583cf582f46
Source dataset
uspto-grants-1996_10
Patent number
US05563136

Reaction notes

Loading…