1-[5-Chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine → 1-[4-(1-Methylethyl)amino-3-pyridazinyl]piperazine

HRID 864399노트

반응식

HRID 864399 반응식
Cl[C:2]1[C:3]([NH:14][CH:15]([CH3:17])[CH3:16])=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:5]=[N:6][CH:7]=1>C(N(CC)CC)C>[CH3:17][CH:15]([NH:14][C:3]1[CH:2]=[CH:7][N:6]=[N:5][C:4]=1[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[CH3:16]

참가 물질

3

반응물 1

HCID 214776731-[5-Chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine

생성물 1

HCID 214776131-[4-(1-Methylethyl)amino-3-pyridazinyl]piperazine

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Following the general procedure of PREPARATION 28 and making non-critical variations but starting with 1-[5-chloro-4-(1-methylethyl)amino-3-pyridazinyl]piperazine (PREPARATION 32, 1.7 g) and triethylamine (0.81 g), the title compound is obtained, NMR (CDCl3) 1.28, 2.06, 3.05, 3.11, 3.59, 4.75, 6.39, and 8.49δ; CMR (CDCl3) 22.2, 43.2, 46.2, 50.6, 103.7, 138.7, 148.4 and 154.5δ.

후처리

  1. customthe general procedure of PREPARATION 28

출처 및 근거

ORD 기록
ord-864356f0d6df4e9796f11f096b6182be
출처 데이터셋
uspto-grants-1996_10
특허 번호
US05563142

반응 노트

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