Fluoroacetyl chloride → HCID 21477695, compound

HRID 864425Notes

Reaction equation

HRID 864425 reaction equation
[F:1][CH2:2][C:3](Cl)=[O:4].[CH2:6]([O:13][C:14]([N:16]1[CH2:21][CH2:20][N:19]([C:22]2[C:27]([NH2:28])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:18][CH2:17]1)=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[CH2:6]([O:13][C:14]([N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:27]([NH:28][C:3](=[O:4])[CH2:2][F:1])=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:20][CH2:21]1)=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 9663Fluoroacetyl chlorideHCID 21477686HCID 21477686, compound

Product 1

HCID 21477695HCID 21477695, compound

Procedure

Following the general procedure of PREPARATION 101 and making non-critical variations but starting with fluoroacetyl chloride (0.94 g), 1-benzyloxycarbonyl-4-[3-amino-2-pyridinyl]piperazine (PREPARATION 100,3.0 g), the title compound is obtained, NMR (300 MHZ, CDCl3) 8.83, 8.65, 8.14, 7.38-7.32, 7.12, 5.17, 4.96, 3.70 and 3.07 δ.

Workup

  1. customthe general procedure of PREPARATION 101

Sources & evidence

ORD record
ord-9c1b397700ca4151939bc2ddc6c2baf3
Source dataset
uspto-grants-1996_10
Patent number
US05563142

Reaction notes

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