Phenyl-2-aminoethyl sulfide → N-Cyano-N'-(2-phenylthioethyl)-N"-3-pyridylguanidine

HRID 864487Notes

Reaction equation

HRID 864487 reaction equation
CS[C:3](=[N:7][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[NH:4][C:5]#[N:6].[C:14]1([S:20][CH2:21][CH2:22][NH2:23])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>N1C=CC=CC=1>[C:5]([NH:4][C:3]([NH:23][CH2:22][CH2:21][S:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[N:7][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)#[N:6]

Participants

4

Reactant 2

HCID 37013Phenyl-2-aminoethyl sulfideHCID 332694S-Methyl N-cyano-N'-3-pyridylisothiourea

Product 1

HCID 178512276N-Cyano-N'-(2-phenylthioethyl)-N"-3-pyridylguanidine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

S-Methyl N-cyano-N'-3-pyridylisothiourea (1.92 g) was dissolved in pyridine (10 ml), and 2-phenylthioethylamine (3.06 g) was added. The mixture was kept at room temperature for 4 days, when it was evaporated in vacuo. The residue was triturated with ether (40 ml), and the resulting suspension was filtered and washed with ether.

Workup

  1. customwhen it was evaporated in vacuo
  2. customThe residue was triturated with ether (40 ml)
  3. filtrationthe resulting suspension was filtered
  4. washwashed with ether

Sources & evidence

ORD record
ord-404a26cd04d44b139f1a74d6ff7410ed
Source dataset
uspto-grants-1996_10
Patent number
US05563160

Reaction notes

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