Triethylamine → HCID 178512275, compound

HRID 864488Notes

Reaction equation

HRID 864488 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=S)=[CH:4][CH:3]=1.[N:21]#[C:22][NH2:23].C1(N=C=NC2CCCCC2)CCCCC1.C(N(CC)CC)C>C(#N)C>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH2:7][CH2:8][NH:9][C:10]([NH:23][C:22]#[N:21])=[N:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 9864CyanamideHCID 10868DicyclohexylcarbodiimideHCID 53938828HCID 53938828, compound

Product 1

HCID 178512275HCID 178512275, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

N-(2-p-Chlorophenoxyethyl)-N'-3-pyridylthiourea (1.05 g) was suspended in acetonitrile (10 ml), and cyanamide (285 mg), N,N'-dicyclohexylcarbodiimide (1.40 g) and triethylamine (0.04 ml) were added. The mixture was kept with stirring at room temperature for a week, when it was filtered, washed with acetonitrile and with ether. The solid mixture of the crude product and N,N'-dicyclohexylthiourea was extracted with chloroform (15 ml) to leave the pure product, which was collected by filtration and washed with chloroform and ether.

Workup

  1. filtrationwhen it was filtered
  2. washwashed with acetonitrile and with ether
  3. additionThe solid mixture of the crude product and N,N'-dicyclohexylthiourea
  4. extractionwas extracted with chloroform (15 ml)
  5. customto leave the pure product, which
  6. filtrationwas collected by filtration
  7. washwashed with chloroform and ether

Sources & evidence

ORD record
ord-23ed2f578cc54d2985c1f6d7c68a7a5f
Source dataset
uspto-grants-1996_10
Patent number
US05563160

Reaction notes

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