Diethyl Ether → N-(5-bromo-3-pyridyl)-N'-cyano-N"-(2-phenylthioethyl)guanidine

HRID 864490Notes

Reaction equation

HRID 864490 reaction equation
CS[C:3](=[N:12][C:13]#[N:14])[NH:4][C:5]1[CH:6]=[N:7][CH:8]=[C:9]([Br:11])[CH:10]=1.[C:15]1([S:21][CH2:22][CH2:23][NH2:24])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.CCOCC>N1C=CC=CC=1>[Br:11][C:9]1[CH:10]=[C:5]([NH:4][C:3]([NH:12][C:13]#[N:14])=[N:24][CH2:23][CH2:22][S:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:6]=[N:7][CH:8]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 37013Phenyl-2-aminoethyl sulfideHCID 178503895HCID 178503895, compound

Product 1

HCID 54221473N-(5-bromo-3-pyridyl)-N'-cyano-N"-(2-phenylthioethyl)guanidine

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

S-Methyl N-(5-bromo-3-pyridyl)-N'-cyanoisothiourea (650 mg) and 2-phenylthioethylamine (740 mg) in pyridine (0.5 ml) were heated to 50° C. for 5 hours. To the resulting clear solution was added ether (10 ml), and the desired pure compound was collected by filtration and washed with ether.

Workup

  1. filtrationthe desired pure compound was collected by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-262f92ccf08e488884e77e502fc46488
Source dataset
uspto-grants-1996_10
Patent number
US05563160

Reaction notes

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