Ammonia → HCID 86749908, compound

HRID 864503Notes

Reaction equation

HRID 864503 reaction equation
C([O:4][CH2:5][C@H:6]1[O:15][C@@H:14]2[C@@H:9]([S:10][C:11]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:12]=3[N:13]2[CH3:16])[C@@H:8]([O:22]C(=O)C)[C@@H:7]1[O:26]C(=O)C)(=O)C.N>CO>[Cl:21][C:18]1[CH:19]=[CH:20][C:11]2[S:10][C@H:9]3[C@@H:8]([OH:22])[C@H:7]([OH:26])[C@@H:6]([CH2:5][OH:4])[O:15][C@H:14]3[N:13]([CH3:16])[C:12]=2[CH:17]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 9846277HCID 9846277, compound

Product 1

HCID 86749908HCID 86749908, compoundYield 55.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The suspension of 1.50 g of the compound (1) obtained in Example 1 in 50 ml of methanol saturated with ammonia was allowed to stand at 4° C. for 24 hours. The reaction solution was concentrated under reduced pressure. To the resulting residue water was added, and the precipitated product was filtered and washed with water, and ether successively. The resulting crude product was recrystallized with 2-propanol to obtain 600 mg (yield: 55.9%) of the title compound.

Workup

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additionTo the resulting residue water was added
  3. filtrationthe precipitated product was filtered
  4. washwashed with water, and ether successively
  5. customThe resulting crude product was recrystallized with 2-propanol

Sources & evidence

ORD record
ord-4c7e98d69e434fbfb4584f20ce8a988b
Source dataset
uspto-grants-1996_10
Patent number
US05563137

Reaction notes

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