反应详情

To the solution of 2.0 g of the compound (36) obtained in Example 35 in 100 ml of acetone, 1.0 g of potassium thioacetate was added, and the mixture was heated with refluxing for 6.5 hours. The solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 1.65 g (yield 96.8% ) of the title compound.

1. temperaturethe mixture was heated
2. temperaturewith refluxing for 6.5 hours
3. customThe solvent was removed under reduced pressure
4. dissolutionthe residue was dissolved in ethyl acetate
5. washThe organic layer was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was removed under reduced pressure