HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium ethanethioate → HCID 86749918, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Reactant | (2R, 3R, 4S, 4aS, 10aR)-8-chloro-3, 4-diacetoxy-10-(2-diethylaminoethyl)-2-(4-methylphenylsulfonyloxy)-2, 3, 4, 4a, 10, 10a-hexahydropyrano [3, 2-b] [1, 4] benzothiazine | HCID 86749916 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 86749918 | HCID 86749918 | 97.4% |
Reaction Steps
To the solution of 2.0 g of the compound (36) obtained in Example 35 in 100 ml of acetone, 1.0 g of potassium thioacetate was added, and the mixture was heated with refluxing for 6.5 hours. The solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate. The organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 1.65 g (yield 96.8% ) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05563137 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-fd8b095a20c04b00982a1f3983b569cf |
| Source note | uspto-grants-1996_10 |