HCID 131719602, compound → HCID 131719600, compound

HRID 864512Notes

Reaction equation

HRID 864512 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10][C@H:9]3[C@@H:11]([OH:37])[C@H:12]([OH:36])[C@@H:13]([CH2:15][O:16][C:17]([C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[O:14][C@H:8]3[N:7]([CH2:38][CH2:39][N:40]([CH2:43][CH3:44])[CH2:41][CH3:42])[C:6]=2[CH:45]=1>CC(C)=O.Cl>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:10][C@H:9]3[C@@H:11]([OH:37])[C@H:12]([OH:36])[C@H:13]([CH2:15][O:16][C:17]([C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[O:14][C@H:8]3[N:7]([CH2:38][CH2:39][N:40]([CH2:43][CH3:44])[CH2:41][CH3:42])[C:6]=2[CH:45]=1

Participants

4

Reactant 1

HCID 131719602HCID 131719602, compound

Product 1

HCID 131719600HCID 131719600, compoundYield 166.6%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolvent

Procedure

To the solution of 500 mg of the compound (34) obtained in Example 33 in 3 ml of acetone, 1.5 ml of hydrochloric acid-saturated diethyl ether was added at 0° C., and the mixture was stirred for 10 minutes. The precipitate was filtered to obtain 440 mg (yield 82.2%) of the title compound.

Workup

  1. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-e082ce62dc4f4a42a31b4fd9f221e23e
Source dataset
uspto-grants-1996_10
Patent number
US05563137

Reaction notes

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