Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfur Dioxide → 4-Chloro-2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfur Dioxide | HCID 1119 | — |
| 반응물 | Ammonium Hydroxide | HCID 14923 | — |
| 반응물 | Methyl 2-amino-6-chlorobenzoate | HCID 592849 | — |
| 반응물 | 4-Methyl-1H-1lambda~6~,2-benzothiazole-1,1,3(2H)-trione | HCID 15934075 | — |
| 반응물 | Methyl 2-chloro-6-(chlorosulfonyl)benzoate | HCID 20488465 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-Chloro-2,3-dihydro-1lambda6,2-benzothiazole-1,1,3-trione | HCID 15567171 | 62% |
반응 단계
4-Chlorosaccharin was prepared by the same method as used for the preparation of 4-methylsaccharin using 4.22 g (0.023 mol) of methyl 6-chloroanthranilate in 22 ml of acetic acid and 40 ml of concentrated hydrochloric acid and 1.68 g (0.024 mol) of sodium nitrite in 7 ml of water to prepare the diazonium salt which was added to 1.93 g (0.011 mol) of cupric chloride dihydrate and 6.5 g of sulfur dioxide in 30 ml of acetic acid and 5 ml of water. The resulting methyl 2-chlorosulfonyl-6-chlorobenzoate was treated with 150 ml of ammonium hydroxide as described above to afford 3.07 g (62%) of 4-chlorosaccharin as a pale yellow solid, mp 245°-246° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05563163 |
| 출처 데이터셋 | uspto-grants-1996_10 |
| ORD ID | ord-beeb0d98631549698f3fbaccc5b71c53 |
| 출처 메모 | uspto-grants-1996_10 |