Sulfuryl chloride → HCID 70044133, compound

HRID 864733Notes

Reaction equation

HRID 864733 reaction equation
C1(S[CH2:8][N:9]2[C:19](=[O:20])[C:18]3[C:13](=[C:14]([CH3:22])[CH:15]=[CH:16][C:17]=3[CH3:21])[S:10]2(=[O:12])=[O:11])C=CC=CC=1.S(Cl)([Cl:26])(=O)=O>>[Cl:26][CH2:8][N:9]1[C:19](=[O:20])[C:18]2[C:13](=[C:14]([CH3:22])[CH:15]=[CH:16][C:17]=2[CH3:21])[S:10]1(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 24648Sulfuryl chlorideHCID 70046405HCID 70046405, compound

Product 1

HCID 70044133HCID 70044133, compoundYield 51%

Procedure

The 0.07 g sample of material obtained in the early fractions from the chromatographic separation described above in Preparation 16A consisting predominantly of 2-phenylthiomethyl-4,7-dimethylsaccharin was reacted with 0.05 ml of sulfuryl chloride in MDC and the product recrystallized from cyclohexane-ethyl acetate to give 20 mg (51%) of 2-chloromethyl-4,7-dimethylsaccharin, mp 107°-108° C.

Workup

  1. customThe 0.07 g sample of material obtained in the early fractions from the chromatographic separation
  2. customthe product recrystallized from cyclohexane-ethyl acetate

Sources & evidence

ORD record
ord-f2cbc3686b4a4cc9b317e1fb57c8ac93
Source dataset
uspto-grants-1996_10
Patent number
US05563163

Reaction notes

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