2,4-Dimethyl-3-pyridinecarboxylic acid → 4-Isopropyl-6-methoxy-4,5,6,7-tetrahydro-2-saccharinylmethyl 2,4-dimethylpyridine-3-carboxylate

HRID 864763Notes

Reaction equation

HRID 864763 reaction equation
Cl[CH2:2][N:3]1[C:13](=[O:14])[C:12]2[CH:11]([CH:15]([CH3:17])[CH3:16])[CH2:10][CH:9]([O:18][CH3:19])[CH2:8][C:7]=2[S:4]1(=[O:6])=[O:5].[CH3:20][C:21]1[C:26]([C:27]([OH:29])=[O:28])=[C:25]([CH3:30])[CH:24]=[CH:23][N:22]=1>>[CH3:20][C:21]1[C:26]([C:27]([O:29][CH2:2][N:3]2[C:13](=[O:14])[C:12]3[CH:11]([CH:15]([CH3:17])[CH3:16])[CH2:10][CH:9]([O:18][CH3:19])[CH2:8][C:7]=3[S:4]2(=[O:6])=[O:5])=[O:28])=[C:25]([CH3:30])[CH:24]=[CH:23][N:22]=1

Participants

3

Reactant 2

HCID 15125612,4-Dimethyl-3-pyridinecarboxylic acidHCID 700440092-Chloromethyl-4-isopropyl-6-methoxy-4,5,6,7-tetrahydrosaccharin

Product 1

HCID 700489454-Isopropyl-6-methoxy-4,5,6,7-tetrahydro-2-saccharinylmethyl 2,4-dimethylpyridine-3-carboxylate

Procedure

It is contemplated that following the procedure of Example 17, 2-chloromethyl-4-isopropyl-6-methoxy-4,5,6,7-tetrahydrosaccharin of preparation 23BJ can be coupled with 2,4-dimethyl-3-pyridinecarboxylic acid to provide 4-isopropyl-6-methoxy-4,5,6,7-tetrahydro-2-saccharinylmethyl 2,4-dimethylpyridine-3-carboxylate.

Sources & evidence

ORD record
ord-94493dcfc4d44f5f9ead1e976ee13be1
Source dataset
uspto-grants-1996_10
Patent number
US05563163

Reaction notes

Loading…