Water → HCID 19417345, compound

HRID 864893Notes

Reaction equation

HRID 864893 reaction equation
[Cl:1][C:2]1[C:7]([CH2:8][C:9]2(O)[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:11]([O:19][CH2:20][CH3:21])[CH:10]2[CH3:22])=[C:6]([Cl:24])[CH:5]=[CH:4][N:3]=1.[OH2:25]>C1(C)C=CC=CC=1.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[C:7]([C:8](=[O:25])[C:9]2[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:11]([O:19][CH2:20][CH3:21])[C:10]=2[CH3:22])=[C:6]([Cl:24])[CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 962WaterHCID 86749927HCID 86749927, compound

Product 1

HCID 19417345HCID 19417345, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 1140TolueneSolvent

Procedure

To the product of step (a) in 30 ml of toluene was added 4 g manganese dioxide. The suspension was refluxed for 7 hours with mechanical stirring and with azeotropic removal of water. The mixture was filtered and the filter cake washed with ether. The solvent was evaporated in vacuo to yield 2.08 g of 2,4-dichloro-3-(3-ethoxy-2-methyl-4-methylsulfonylbenzoyl)pyridine as a brown semi-solid.

Workup

  1. temperatureThe suspension was refluxed for 7 hours
  2. filtrationThe mixture was filtered
  3. washthe filter cake washed with ether
  4. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-be92735351774f1f8250ab14509743c6
Source dataset
uspto-grants-1996_10
Patent number
US05565413

Reaction notes

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