HCID 19417346, compound → HCID 136032772, compound

HRID 864895Notes

Reaction equation

HRID 864895 reaction equation
C([O:8][C:9]1[C:14]([C:15](=[O:30])[C:16]2[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:24])=[O:23])=[C:18]([O:26][CH2:27][CH3:28])[C:17]=2[CH3:29])=[C:13]([O:31]CC2C=CC=CC=2)[CH:12]=[CH:11][N:10]=1)C1C=CC=CC=1>O1CCOCC1.[Pd]>[OH:31][C:13]1[CH:12]=[CH:11][NH:10][C:9](=[O:8])[C:14]=1[C:15](=[O:30])[C:16]1[CH:21]=[CH:20][C:19]([S:22]([CH3:25])(=[O:23])=[O:24])=[C:18]([O:26][CH2:27][CH3:28])[C:17]=1[CH3:29]

Participants

4

Reactant 1

HCID 19417346HCID 19417346, compound

Product 1

HCID 136032772HCID 136032772, compoundYield 101.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of step (c) (0.387 g) in 8 ml dioxane was added 110 mg of 10% palladium on carbon (Degussa type, water wet). The mixture was then shaken for 5 hours, filtered and the filter cake washed. The solvents were evaporated to yield 260 mg of 4-hydroxy-3-(3-ethoxy-2-methyl-4-methylsulfonylbenzoyl)pyrid-2-one.

Workup

  1. filtrationfiltered
  2. washthe filter cake washed
  3. customThe solvents were evaporated

Sources & evidence

ORD record
ord-266f74485d184b209512ccbf58229e1c
Source dataset
uspto-grants-1996_10
Patent number
US05565413

Reaction notes

Loading…