Ethyl diazoacetate → HCID 67686033, compound

HRID 864949Notes

Reaction equation

HRID 864949 reaction equation
C([O:3][C:4](=[O:8])[CH:5]=[N+:6]=[N-:7])C.[CH3:9]O[C:11](C)(C)[CH3:12]>>[NH:6]1[C:5]([C:4]([OH:3])=[O:8])=[CH:12][CH:11]=[N:7]1.[NH:7]1[CH2:9][CH:4]=[CH:5][NH:6]1

Participants

3

Reactant 2

HCID 12192Ethyl diazoacetate2×HCID 15413tert-Butyl methyl ether

Product 1

HCID 67686033HCID 67686033, compound

Procedure

The reaction of trimethylphosphonoacrylate and ethyldiazoacetate was carded out as follows. Trimethylphosphonoacrylate (1.0 g, 5.15 mmol) was dissolved in methyl-t-butyl ether followed by ethyl diazoacetate (0.60 g, 5.26 mmol). After stirring overnight, the reaction was filtered and the resultant solid (880 mg, 55%) recrystallized from acetone-hexane to afford off-white granules of the pyrazoline 1H-Pyrazole-5-carboxylic-acid, 3-carboethoxy-5-(dimethoxyphosphinyl)-4,5-dihydro, methyl ester (699 mg) mp 100°-102°.

Workup

  1. filtrationthe reaction was filtered
  2. customthe resultant solid (880 mg, 55%) recrystallized from acetone-hexane

Sources & evidence

ORD record
ord-911ecfce623f4152aad5c6b4f8bfd455
Source dataset
uspto-grants-1996_10
Patent number
US05565441

Reaction notes

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