Sodium Hydroxide → HCID 135497257, compound

HRID 865003Notes

Reaction equation

HRID 865003 reaction equation
[OH-].[Na+].[CH2:3]([C:7]1[N:12]=[CH:11][NH:10][C:9](=[O:13])[C:8]=1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]([O:29]C)=[O:28])=[CH:17][CH:16]=1)[CH2:4][CH2:5][CH3:6].O.CCOCC>O.CO>[CH2:3]([C:7]1[N:12]=[CH:11][NH:10][C:9](=[O:13])[C:8]=1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[C:27]([OH:29])=[O:28])=[CH:17][CH:16]=1)[CH2:4][CH2:5][CH3:6]

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 21584184Diethylether waterHCID 135513973HCID 135513973, compound

Product 1

HCID 135497257HCID 135497257, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

0.13 g of NaOH dissolved in 2 ml of H2O were added to a solution containing 0.42 g of 6-butyl-5-[(2'-methoxycarbonylbiphenyl-4-yl) methyl]pyrimidin-4-one in 10 ml of MeOH. After refluxing for 24 hours under stirring the solvent was evaporated. The residue was dissolved in H2O and extracted with Et2O. The aqueous phase was acidified to pH 3. The so obtained waxy solid was treated with a H2O/Et2O mixture. After filtering, 0.35 g of a white solid was obtained (yield 88%; m.p.=197°-200° C.).

Workup

  1. additionwere added to a solution
  2. temperatureAfter refluxing for 24 hours
  3. customwas evaporated
  4. dissolutionThe residue was dissolved in H2O
  5. extractionextracted with Et2O
  6. customThe so obtained waxy solid
  7. filtrationAfter filtering

Sources & evidence

ORD record
ord-b86017feef3a44adaedef1533e4dc840
Source dataset
uspto-grants-1996_10
Patent number
US05565464

Reaction notes

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