Sodium Hydroxide → HCID 135497257, compound

Participants

Reaction Steps

0.13 g of NaOH dissolved in 2 ml of H2O were added to a solution containing 0.42 g of 6-butyl-5-[(2'-methoxycarbonylbiphenyl-4-yl) methyl]pyrimidin-4-one in 10 ml of MeOH. After refluxing for 24 hours under stirring the solvent was evaporated. The residue was dissolved in H2O and extracted with Et2O. The aqueous phase was acidified to pH 3. The so obtained waxy solid was treated with a H2O/Et2O mixture. After filtering, 0.35 g of a white solid was obtained (yield 88%; m.p.=197°-200° C.).

Provenance & Evidence