Phenyl isocyanate → HCID 135556636, compound

HRID 865004Notes

Reaction equation

HRID 865004 reaction equation
[C:1]1([N:7]=[C:8]=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[NH:16][C:15](=[O:17])[C:14]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]([O:33][CH3:34])=[O:32])=[CH:21][CH:20]=2)=[C:13]([CH2:35][CH2:36][CH2:37][CH3:38])[N:12]=1>CN(C=O)C>[CH2:35]([C:13]1[N:12]=[C:11]([NH:10][C:8]([NH:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[O:9])[NH:16][C:15](=[O:17])[C:14]=1[CH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[C:31]([O:33][CH3:34])=[O:32])=[CH:21][CH:20]=1)[CH2:36][CH2:37][CH3:38]

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 135703295HCID 135703295, compound

Product 1

HCID 135556636HCID 135556636, compoundYield 56.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.27 g of phenylisocyanate were added to a solution containing 0.3 g of 2-amino-6-butyl-5-[(2'-methoxycarbonylbiphenyl-4-yl) -methyl]pyrimidin-4-one in ml of dry DMF at 0° C. After stirring at room temperature for 30 minutes the mixture was evaporated to dryness and the residue was crystallized from DMF; 0.22 g of a white solid was obtained (yield 56%, m.p. 217°-219° C.).

Workup

  1. customwas evaporated to dryness
  2. customthe residue was crystallized from DMF

Sources & evidence

ORD record
ord-52c2389807904a63af84524a028d4036
Source dataset
uspto-grants-1996_10
Patent number
US05565464

Reaction notes

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