反应详情

To 3.98 g of 2-methylnaphtho[1,2-d]thiazole dissolved in carbon tetrachloride (40 ml) was added 3.56 g of N-bromosuccinimide and 0.20 g of benzoyl peroxide, followed by 6 hours of heating under reflux. After cooling the reaction solution, insoluble matter was removed by filtration, and the solvent was evaporated. The residue was subjected to silica gel column chromatography eluted with hexane-chloroform (5:1) to obtain 3.50 g (63%) of 2-bromomethylnaphtho[1,2-d]thiazole.

1. temperatureof heating
2. temperatureunder reflux
3. temperatureAfter cooling the reaction solution, insoluble matter
4. customwas removed by filtration
5. customthe solvent was evaporated
6. washeluted with hexane-chloroform (5:1)