1-Butanol → HCID 15180173, compound

HRID 865200Notes

Reaction equation

HRID 865200 reaction equation
[Na].Cl[C:3]1[C:7]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:6][O:5][N:4]=1.[CH2:14]([OH:18])[CH2:15][CH2:16][CH3:17]>>[CH2:14]([O:18][C:3]1[C:7]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:6][O:5][N:4]=1)[CH2:15][CH2:16][CH3:17]

Participants

4

Reactant 3

HCID 2631-ButanolHCID 5360545SodiumHCID 15180172HCID 15180172, compound

Product 1

HCID 15180173HCID 15180173, compound

Conditions

Temperature
25 °C

Procedure

To a solution of sodium (150 mg, 6.5 mmol) in 1-butanol (5 ml) was added 3-(3-chloro-1,2,5-oxadiazol-4-yl)pyridine (350 mg, 1.9 mmol). The mixture was stirred at 25° C. for 2 h and evaporated. The residue was dissolved in water and extracted with ether. The combined organic phases were dried and evaporated to give the title compound.

Workup

  1. customevaporated
  2. dissolutionThe residue was dissolved in water
  3. extractionextracted with ether
  4. customThe combined organic phases were dried
  5. customevaporated

Sources & evidence

ORD record
ord-36be6c0898774bd2a6f83a6af48b5b11
Source dataset
uspto-grants-1996_10
Patent number
US05565475

Reaction notes

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