HCID 19075384, compound → HCID 19075385, compound

HRID 865223Notes

Reaction equation

HRID 865223 reaction equation
Cl.[C:2]([CH2:5][CH2:6][CH2:7][S:8][C:9]1[C:13]([C:14]2[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][CH:19]=2)=[N:12][S:11][N:10]=1)([OH:4])=[O:3]>Cl>[C:2]([CH2:5][CH2:6][CH2:7][S:8][C:9]1[C:13]([C:14]2[CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][CH:19]=2)=[N:12][S:11][N:10]=1)([OH:4])=[O:3]

Participants

3

Reactant 1

HCID 19075384HCID 19075384, compound

Product 1

HCID 19075385HCID 19075385, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3-(3-(3-carboxypropylthio)-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine hydrochloride (0.70 g, 2 mmol) in concentrated hydrochloric acid (10 ml) was heated at reflux for 6 hours. The reaction mixture was evaporated at reduced pressure. The residue was dissolved in water and neutralized with a sodiumhydroxide solution giving the title compound in 80% yield. M.p. 99°-101° C. Compound 258.

Workup

  1. temperatureat reflux for 6 hours
  2. customThe reaction mixture was evaporated at reduced pressure
  3. dissolutionThe residue was dissolved in water

Sources & evidence

ORD record
ord-1ef8e67b68f64d27b2859db60d056503
Source dataset
uspto-grants-1996_10
Patent number
US05565475

Reaction notes

Loading…