Thionyl Chloride → 2-n-butyl-1-(2-chlorophenyl)methyl-5chloromethyl-1H-imidazole hydrochloride

HRID 865230Notes

Reaction equation

HRID 865230 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:7]([CH2:10]O)=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].S(Cl)([Cl:22])=O>>[ClH:19].[CH2:1]([C:5]1[N:6]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:7]([CH2:10][Cl:22])=[CH:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 100164181H-Imidazole-5-methanol, 2-butyl-1-[(2-chlorophenyl)methyl]-

Product 1

HCID 193515432-n-butyl-1-(2-chlorophenyl)methyl-5chloromethyl-1H-imidazole hydrochloride

Procedure

A mixture of 2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole (1 g) was refluxed with thionyl chloride (20 mL) for 2 hours. The reaction mixture was evaporated in vacuo and the residue was triturated with diethyl ether to give 1.08 g of 2-n-butyl-1-(2-chlorophenyl)methyl-5-chloromethyl-1H-imidazole hydrochloride.

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. customthe residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-871f8e71f37a4ef680c3c04eacfe6094
Source dataset
uspto-grants-1996_10
Patent number
US05565480

Reaction notes

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