HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-n-butyl-1-(2-chlorophenyl)methyl-5chloromethyl-1H-imidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1H-Imidazole-5-methanol, 2-butyl-1-[(2-chlorophenyl)methyl]- | HCID 10016418 | — |
| Product | 2-n-butyl-1-(2-chlorophenyl)methyl-5chloromethyl-1H-imidazole hydrochloride | HCID 19351543 | — |
Reaction Steps
A mixture of 2-n-butyl-1-(2-chlorophenyl)methyl-5-hydroxymethyl-1H-imidazole (1 g) was refluxed with thionyl chloride (20 mL) for 2 hours. The reaction mixture was evaporated in vacuo and the residue was triturated with diethyl ether to give 1.08 g of 2-n-butyl-1-(2-chlorophenyl)methyl-5-chloromethyl-1H-imidazole hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05565480 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-871f8e71f37a4ef680c3c04eacfe6094 |
| Source note | uspto-grants-1996_10 |