4-Chlorophenyl Isocyanate → N-[[(4-chlorophenyl) amino]-carbonyl]-4-(4-morpholinyl) benzenesulfonamide

HRID 865316Notes

Reaction equation

HRID 865316 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][CH:3]=1.[N:11]1([C:17]2[CH:22]=[CH:21][C:20]([S:23]([NH2:26])(=[O:25])=[O:24])=[CH:19][CH:18]=2)[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:26][S:23]([C:20]2[CH:19]=[CH:18][C:17]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[CH:22][CH:21]=2)(=[O:24])=[O:25])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 76934-Chlorophenyl IsocyanateHCID 7354354-(Morpholin-4-yl)benzene-1-sulfonamide

Product 1

HCID 15345719N-[[(4-chlorophenyl) amino]-carbonyl]-4-(4-morpholinyl) benzenesulfonamide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-Chlorophenylisocyanate (2.61 g, 17 moles) was dissolved in 16 ml of acetone and was then added dropwise to the sulfonamide solution. The mixture was then stirred overnight at room temperature, resulting in the formation of a white solid.

Workup

  1. customresulting in the formation of a white solid

Sources & evidence

ORD record
ord-fdccf3362d874d0bba3eb0d86506ba63
Source dataset
uspto-grants-1996_10
Patent number
US05565494

Reaction notes

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