反应详情

To a solution of 1.008 g (4.84 mmol) of methyl 3-iso-butyl-4-hydroxybenzoate and 1.737 g (6.05 mmol) of ethyl α-bromo-3,4-methylenedioxyphenylacetate in 10 mL of acetone was added 1.338 g (10 mmol) of finely powdered potassium carbonate. The reaction mixture was magnetically stirred and refluxed for 4 hours, then cooled to room temperature, filtered and evaporated. The residue was purified on a silica gel flash chromatography column eluted with 10% EtOAc-hexane; combination of the purified fractions and drying in vacuo afforded 1.518 g (76%) of the title compound as an amorphous powder.

1. temperaturerefluxed for 4 hours
2. filtrationfiltered
3. customevaporated
4. customThe residue was purified on a silica gel flash chromatography column
5. washeluted with 10% EtOAc-hexane
6. customcombination of the purified fractions and drying in vacuo