HCID 178455855, compound → HCID 178460926, compound

HRID 865611Notes

Reaction equation

HRID 865611 reaction equation
[CH2:1]([Mg]Cl)[CH2:2][CH3:3].Cl[SiH:7]1[CH2:12][CH2:11][CH:10]([C@H:13]2[CH2:18][CH2:17][C@H:16]([O:19][CH3:20])[CH2:15][CH2:14]2)[CH2:9][CH2:8]1>O1CCCC1>[CH3:20][O:19][CH:16]1[CH2:17][CH2:18][CH:13]([C@H:10]2[CH2:11][CH2:12][Si@H:7]([CH2:1][CH2:2][CH3:3])[CH2:8][CH2:9]2)[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 178455855HCID 178455855, compoundHCID 178496546HCID 178496546, compound

Product 1

HCID 178460926HCID 178460926, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

100 ml of a tetrahydrofuran solution of 1.0M n-propyl magnesium chloride was dripped into a mixture of 23.0 g (93.2 mmol) of 1-chloro-4-(trans-4-methoxycyclohexyl)-1-silacyclohexane and 100 ml of tetrahydrofuran. After a conventional after treatment, the product thus obtained was purified by means of silica-gel column chromatography to obtain 17.1 g (yield 72%) of the trans, trans isomer.

Workup

  1. customAfter a conventional after treatment, the product thus obtained
  2. customwas purified by means of silica-gel column chromatography
  3. customto obtain 17.1 g (yield 72%) of the trans, trans isomer

Sources & evidence

ORD record
ord-7e86c5200ae340c69eea717904d28d25
Source dataset
uspto-grants-1996_10
Patent number
US05567350

Reaction notes

Loading…