Thionyl Chloride → HCID 178523385, compound

HRID 865652Notes

Reaction equation

[C:1]([NH:11][CH2:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([C:19]([OH:21])=O)[CH2:15][CH2:14]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].S(Cl)([Cl:24])=O>CCCCC>[C:1]([NH:11][CH2:12][C@H:13]1[CH2:18][CH2:17][C@H:16]([C:19]([Cl:24])=[O:21])[CH2:15][CH2:14]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

Participants

Conditions

Temperature: 40 °C

Procedure

A mixture of trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carboxylic acid (5.02 g, 17.3 mmol), prepared as in step 1, and thionyl chloride was heated at 40° C. for 30 minutes. The reaction mixture was cooled to ambient temperature and diluted with pentane (50 mL). Trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride (4.37 g) was isolated by filtration and drying in vacuo.

Workup

temperatureThe reaction mixture was cooled to ambient temperature

Sources & evidence

ORD record: ord-47b88d1fd2d1406f8bdea0bbcfd9ac6c
Source dataset: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05567711

Reaction notes

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