HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl methylmalonate → HCID 23374604, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl methylmalonate | HCID 11857 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(Bromomethyl)-3-(trifluoromethyl)benzene | HCID 123061 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23374604 | HCID 23374604 | — |
Reaction Steps
Diethyl 2-methylmalonate was converted, in THF, into the anion using 1 eq. of sodium hydride and alkylated with 1.05 eq. of 3-trifluoromethylbenzyl bromide. After working up in the standard manner, diethyl 2-methyl-2-(3-trifluoromethylbenzyl)malonate was obtained. Colorless oil, MS (ES):333 (M+1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05567734 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-f82305348c864667ac2ef129edebb2d1 |
| Source note | uspto-grants-1996_10 |