Diethyl methylmalonate → HCID 23374604, compound

HRID 865679Notes

Reaction equation

HRID 865679 reaction equation
[CH3:1][CH:2]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[H-].[Na+].[F:15][C:16]([F:26])([F:25])[C:17]1[CH:18]=[C:19]([CH:22]=[CH:23][CH:24]=1)[CH2:20]Br>C1COCC1>[CH3:1][C:2]([CH2:20][C:19]1[CH:22]=[CH:23][CH:24]=[C:17]([C:16]([F:15])([F:25])[F:26])[CH:18]=1)([C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

5

Reactant 3

HCID 11857Diethyl methylmalonateHCID 24758Sodium hydrideHCID 1230611-(Bromomethyl)-3-(trifluoromethyl)benzene

Product 1

HCID 23374604HCID 23374604, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Diethyl 2-methylmalonate was converted, in THF, into the anion using 1 eq. of sodium hydride and alkylated with 1.05 eq. of 3-trifluoromethylbenzyl bromide. After working up in the standard manner, diethyl 2-methyl-2-(3-trifluoromethylbenzyl)malonate was obtained. Colorless oil, MS (ES):333 (M+1)

Sources & evidence

ORD record
ord-f82305348c864667ac2ef129edebb2d1
Source dataset
uspto-grants-1996_10
Patent number
US05567734

Reaction notes

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