反应详情

温度

110 °C

A mixture of 0.4 g of 2-chloro-7-nitro-6-trifluoromethoxybenzothiazole and 10 cm3 of 33% aqueous ammonium hydroxide solution in 30 cm3 of ethanol is heated at 110° C. in an autoclave for 5 hours. The mixture is cooled and the solvent is evaporated off under reduced pressure (2.7 kPa). After purification by flash chromatography on silica with a cyclohexane/ethyl acetate mixture (4/6 by volume) as eluent, 0.22 g of 2-amino-7-nitro-6-trifluoromethoxybenzothiazole is obtained, melting at 180° C.

1. temperatureThe mixture is cooled
2. customthe solvent is evaporated off under reduced pressure (2.7 kPa)
3. customAfter purification by flash chromatography on silica with a cyclohexane/ethyl acetate mixture (4/6 by volume) as eluent