Triethyl phosphite → Diethyl (Methoxymethyl)phosphonate

HRID 865870Notes

Reaction equation

HRID 865870 reaction equation
C([O:3][P:4]([O:8][CH2:9][CH3:10])[O:5][CH2:6][CH3:7])C.[CH3:11][O:12][CH2:13]Br>>[CH3:11][O:12][CH2:13][P:4](=[O:3])([O:5][CH2:6][CH3:7])[O:8][CH2:9][CH3:10]

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 83093Bromomethyl methyl ether

Product 1

HCID 11658394Diethyl (Methoxymethyl)phosphonateYield 98%

Procedure

To a sample of 17.90 mL (0.104 mol) of triethylphosphite at -78° C. under argon was added, dropwise 8.50 mL (0.104 mol) of bromomethyl methyl ether. The mixture slowly warmed to RT and stirred for 24 h, when it was fractionally distilled 100° C., 5 mm) to provide 16.22 g (98%) of title compound as a pale yellow oil.

Workup

  1. customwas fractionally distilled 100° C.

Sources & evidence

ORD record
ord-22ce5bd3bb7c4d2d8fbd7406a49ad39c
Source dataset
uspto-grants-1996_10
Patent number
US05567841

Reaction notes

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